Tumoral calcinosis is an uncommon type of extraosseous calcification
characterized by large rubbery or cystic masses containing calcium-phosphate
deposits. The condition prevails in the periarticular tissue with preservation
of osteoarticular structures. Elevated calcium-phosphorus products and severe
secondary hyperparathyroidism are present in most patients with uremic tumoral
calcionosis (UTC). Case report of an obese secondary to chronic
glomerulonephritis, undergoing continuous ambulatory peritoneal dialysis (CAPD)
reported the appearance of painless tumors in the medial surface of fifth finger
and left arm. Tumoral calcinosis was confirmed by left biceps biopsy. Poor
adherence to CAPD. The patient was transferred to the "tidal" modality of
peritoneal dialysis and after was treated by hemodialysis, despite the
persistence of severe hyperparathyroidism progressive reduction of UTC until
near to its complete disappearance. Nowadays, one year after patient received
deceased-donor kidney transplantation, he presents with an improvement in
secondary hyperparathyroidism. UTC should be included in the elucidation of
periarticular calcification of every patient on dialysis. Relevant laboratory
findings such as secondary hyperparathyroidism and elevated calcium- phosphorus
products in the presence of periarticular calcification should draw attention
the diagnosis of UTC.
Keywords: calcium metabolism disorders; nephrology; phosphorus metabolism disorders.
A calcinose tumoral é um tipo raro de calcificação extraóssea caracterizada por
grandes massas císticas e elásticas contendo depósitos de fosfato de cálcio.
condição é mais prevalente no tecido periarticular e preserva estruturas
osteoarticulares. A elevação do produtos cálcio-fósforo e o hiperparatireoidismo
secundário grave estão presentes na maioria dos pacientes com calcinose tumoral
urêmica (UTC). O relato de caso em questão refere-se a um homem de 22 anos,
branco, obeso, com doença renal crônica secundária à glomerulonefrite crônica,
em diálise peritoneal ambulatorial contínua (CAPD), que apresentou aparecimento
de tumores indolores na face medial do quinto quirodáctilio e braço esquerdo.
calcinose tumoral foi confirmada por biópsia do bíceps esquerdo. O paciente
apresentava baixa adesão à CAPD. Foi transferido para a modalidade de diálise
peritoneal e depois iniciou tratamento por hemodiálise. Apesar da persistência
do hiperparatireoidismo grave, houve redução progressiva da UTC, com resolução
próxima do seu desaparecimento completo. Há 1 ano o paciente foi submetido a
transplante renal, doador falecido, e apresentou melhora do hiperparatiroidismo
secundário. A UTC deve ser incluída na elucidação de calcificação periarticular
de pacientes em diálise. Os achados laboratoriais relevantes, tais como
hiperparatiroidismo secundário e elevação dos produtos cálcio-fósforo na
presença de calcificação periarticular, devem chamar a atenção para o
diagnóstico da UTC.
Palavras-chave: distúrbios do metabolismo do cálcio; distúrbios do metabolismo do fósforo; nefrologia.
|Citation: Maioli ME, Delfino VDA, Guerra ACDZ, Kunii LF, Frange RFN. Reversal of uremic tumoral calcinosis by optimization of clinical treatment of bone and mineral metabolism disorder. Braz. J. Nephrol. (J. Bras. Nefrol.) 39(02):217. doi:10.5935/0101-2800.20170037|
|Received: July 01 2016; Accepted: August 30 2016|
Tumoral calcinosis is an uncommon type of extraosseous calcification characterized by large rubbery or cystic masses containing calcium-phosphate deposits.1 The condition prevails in the periarticular tissue with preservation of osteoarticular structures. Genetic causes and metabolic disorders are associated with their appearance.2 The tumoral calcinosis that occurs in chronic kidney disease (CKD) patients is known for uremic tumoral calcinosis (UTC).
In this condition, calcifications can also contain hydroxyapatite (Ca5 (PO4) 3OH).1,3 Although, most often described in hemodialysis (HD) patients (0.5- 1.2% prevalence),2 UTC may also occur in patients undergoing peritoneal dialysis. Elevated calcium-phosphorus products and severe secondary hyperparathyroidism are present in most patients with UTC.4
Common sites of involvement are the blood vessels, periarticular region, heart, lungs, kidneys, gastric mucosa, central nervous system, breast and eyes. Clinical treatment for UTC includes dietary phosphorus restriction, non-calcium phosphate binders, calcimimetics, optimal control of hyperparathyroidism, and intensive hemodialysis with low calcium dialysate. Surgical excision of tumoral calcinosis, parathyroidectomy, and kidney transplantation are recommended for persistent or refractory UTC.1,5
An obese (Body Mass Index 38.5) young white man of 22 years with CKD secondary to chronic glomerulonephritis, undergoing continuous ambulatory peritoneal dialysis (CAPD) for uremia management, reported, after 6 months of treatment, the appearance of painless tumors in the medial surface of fifth finger and left arm (biceps region).
Laboratory results: serum calcium 8.5 mg/dL (reference: 8.4 to 10.2 mg/dL), serum albumin 3.6 mg/dL (reference: 3.4 to 5.2 mg/dL), serum phosphorus 11.1 mg/dL (reference: 2.5 to 4.5 mg/dL), and intact PTH (iPTH) 1867 pg/mL (reference: 15 to 65 pg/ml), serum uric acid 8.7 mg/dL (reference: 3.6 to 7.7 mg/dL).
Computed tomography of the left arm and radiography of the right hand (Figure. 1) showed periarticular, irregular and multilobular calcifications. Tumoral calcinosis was confirmed by left biceps biopsy: lesion characterized by the presence of abundant giant cells scattered throughout the proliferation of fibroblasts, with associated areas of hemorrhage and extensive calcifications. Ultrasonography of anterior cervical region showed no nodules in the four parathyroid glands.
Questioned, the patient admitted poor adherence to CAPD (with 3.5 mEq/L calcium concentration in dialysate), sometimes doing only one or two exchanges a day. The patient was transferred to the "tidal" modality of peritoneal dialysis in order to increase the efficiency of uremia treatment, while waiting for AVF maturation for starting HD.
With the "tidal" modality, there was an improvement in laboratory levels of bone metabolism: serum calcium 8.0 mg/dL, serum phosphorus 7.8 mg /dL and iPTH of 300.5 pg/mL. After a short stay in "tidal" CAPD, the patient was treated for 2.5 years by HD (three sessions per week, four hours per session, with 3.0 mEq/L calcium in the dialysis bath). During this period, he made use of sevelamer, calcitriol and calcium carbonate (the latter two when calcium x phosphorus product allowed it).
After 3 months on hemodialysis, it was observed, despite the persistence of severe hyperparathyroidism (calcium 8.9 mg/dL, P 7.6 mg/dL and PTH 1840 pg/mL), progressive reduction of UTC until near to its complete disappearance (Figure. 2). In November 2014, the patient received deceased-donor kidney transplantation (immunosuppression: tacrolimus, mycophenolate mofetil, and prednisone).
Nowadays, three months after surgery, he presents with a serum creatinine of 0.9 mg/dL and calcium, phosphorus and iPTH values of 9.4 mg/dL; 1.7 mg/dL and 368.8 pg/mL, respectively. Since there was improvement in hyperparathyroidism by normalization of renal function, no hypercalcemia, moderate hypophosphatemia, thus was vitamin D nutritional supplemented by low serum.
Since no abnormal parathyroid glands was identified at their usual position at ultrasound, it was planned to observe for a few months more the possibility of reversal the secondary hyperparathyroidism, as suggested in the Literature,6 instead considering parathyroidectomy as a first approach of treatment.6
UTC should be included in the elucidation of periarticular calcification of every patient on dialysis. The diagnosis is often not done due to its rarity and the difficulty of clinical recognition. In patients on peritoneal dialysis, there is a report of adherence to dialysis, as exemplified in this case.5
Relevant laboratory findings such as secondary hyperparathyroidism and elevated calcium-phosphorus products in the presence of periarticular calcification should draw attention to the diagnosis of UTC. Treatment involves dialysis improvement, and appropriate control of calcium and phosphorus. Parathyroidectomy and kidney transplantation may be required for its management.